Episode 10: Caged Heat - Meg kidnaps Sam and Dean and tries to force them to tell her where Crowley is hiding. Sam makes her a deal - they will help her find Crowley if she promises to torture him for information about how to get Sam's soul back. Castiel joins the fight but finds it difficult to work with Meg.

Episode 9: Clap Your Hands If You Believe - While Sam and Dean are investigating a UFO sighting, Dean is abducted from a crop circle. However, when he awakens, he discovers he isn't dealing with aliens, but fairies! Unfortunately, only Dean can see the fairy that keeps attacking him which makes tracing and stopping them difficult.

Episode 8: All Dogs Go to Heaven - Dean and Sam investigate what seems to be a werewolf killing but turns out to be a skinwalker posing as a family dog who is taking revenge on his owner's enemies. After capturing the dog, he turns human and tells Sam and Dean that an Alpha skinwalker has created many sleeper cells that will rise on his command and kill their families. The only way to stop the mass murders is to find and kill the Alpha.

Episode 7: Family Matters - Dean becomes suspicious of Samuel's motives, but Sam isn't sold on the idea that their grandfather is doing anything wrong. The brothers go along on a hunt with Samuel and the other Campbells, but things go terribly awry.

Episode 6: You Can't Handle the Truth - When several people kill themselves after asking for the truth, Sam and Dean investigate and realize that Veritas, an ancient goddess of truth, has been summoned. Her victims die when the hear more truth than they can stand. However, when Dean is cursed, he decides to take advantage of the situation to ask Sam a few questions.

Episode 5: Live Free or Twi-hard - After a group of young girls go missing, Sam and Dean realize that a group of vampires have taken up residence in the small town. After a fight with two of the blood-suckers, Dean is bitten and turns into a vampire. Samuel tells Dean he can change him back but he'd have to get the blood of the vampire who turned him. Dean infiltrates the nest and runs into the Alpha.

Episode 4: Weekend at Bobby's - Bobby turns to Sam and Dean for help when the demon Crowley refuses to return his soul as agreed.

Episode 3: The Third Man - Sam and Dean call Castiel for help when they investigate a case about several dead police officers who seem to have been killed by the plagues of Egypt. Castiel confirms the staff of Moses was used to kill the cops and tells Sam and Dean that Heaven is in a state of chaos and God’s weapons have been stolen. The three head off to find the thief and come face to face with an old enemy.

Episode 2: Two and a Half Men - Sam turns to Dean for help when he's forced to take in the baby of parents murdered by shapeshifters. However, the brothers realize they have more problems when they discover that the baby is a shapeshifter... and it's father will stop at nothing to recover it.

Episode 1: Exile On Main St - It’s a year later and Dean has given up hunting and is living with Lisa and her son Ben. Mysteriously freed from his cage in hell, Sam finds Dean and tells him he need to rejoin the fight and introduces Dean to a world — a family — he never even knew existed: the Campbells, his mother’s family, lead by none other than their Grandfather